Identification and characterization of fluoroquinolone non-susceptible Streptococcus pyogenes clones harboring tetracycline and macrolide resistance in Shanghai, China

Y Shen; J Cai; MR Davies; C Zhang; K Gao; D Qiao; H Jiang; W Yao; Y Li; M Zeng; M Chen

Journal article

Identification and characterization of fluoroquinolone non-susceptible Streptococcus pyogenes clones harboring tetracycline and macrolide resistance in Shanghai, China

Y Shen, J Cai, MR Davies, C Zhang, K Gao, D Qiao, H Jiang, W Yao, Y Li, M Zeng, M Chen

Frontiers in Microbiology | FRONTIERS MEDIA SA | Published : 2018

DOI: 10.3389/fmicb.2018.00542

Download PDF

Abstract

Streptococcus pyogenes, also known as group A Streptococcus (GAS), is one of the top 10 infectious causes of death worldwide. Macrolide and tetracycline resistant GAS has emerged as a major health concern in China coinciding with an ongoing scarlet fever epidemic. Furthermore, increasing rates of fluoroquinolone (FQ) non-susceptibility within GAS from geographical regions outside of China has also been reported. Fluoroquinolones are the third most commonly prescribed antibiotic in China and is an therapeutic alternative for multi-drug resistant GAS. The purpose of this study was to investigate the epidemiological and molecular features of GAS fluoroquinolone (FQ) non-susceptibility in Shangh..

View full abstract

University of Melbourne Researchers

Mark Davies Author

Related Projects (2)

INTEROGATION OF THE GENOMIC EPIDEMIOLOGY AND NEPHRITOGENICITY WITHIN INDIGENOUS REGIONS ENDEMIC FOR GROUP A STREPTOCOCCAL DISEASE

Group A streptococcal (GAS) bacterial infections within the Indigenous populations of Northern Australia are amongst the highest in the worl..

WORLDWIDE MOLECULAR ANALYSIS OF STREPTOCOCCUS PYOGENES SCARLET FEVER OUTBREAKS

The microorganism group A Streptococcus (also called GAS or Streptococcus pyogenes) ranks among the top 10 infectious disease killers of hum..

Grants

Awarded by Natural Science Foundation of Shanghai

Funding Acknowledgements

This study was supported by grants from National Natural Science Foundation of China (81601801), Shanghai Rising-Star Program (17QA1403100), a Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai (2017YQ039), Natural Science Foundation of Shanghai (16ZR1433300), and Key project funded by Shanghai Municipal Commission of Health and Family Planning (201640002). MD is supported by the National Health and Medical Research Council of Australia (NHMRC) grants 1126805 and 1130455. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.